Genetic Factors of Teeth Impaction: Polymorphic and Haplotype Variants of PAX9, MSX1, AXIN2, and IRF6 Genes.

In recent research, there has been a growing awareness of the role of genetic factors in the positioning and eruption of teeth in the maxilla and mandible. This study aimed to evaluate the potential of specific polymorphic markers of single nucleotide polymorphisms (SNPs) located within the PAX9, MSX1, AXIN2, and IRF6 genes to determine the predisposition to tooth impaction. The study participants were divided into two groups: the first group consisted of individuals with at least one impacted secondary tooth. In contrast, the second group (control group) had no impacted teeth in their jaws. To analyze the genes, real-time PCR (polymerase chain reaction) and TaqMan probes were utilized to detect the selected polymorphisms. The findings suggest that disruptions in the structure and function of the mentioned genetic factors such as polymorphic and haplotype variants of PAX9, MSX1, AXIN2, and IRF6 genes, which play a direct role in tooth and periodontal tissue development, might be significant factors in tooth impaction in individuals with genetic variations. Therefore, it is reasonable to hypothesize that tooth impaction may be influenced, at least in part, by the presence of specific genetic markers, including different allelic variants of the PAX9, AXIN2, and IRF6 genes, and especially MSX1.

Oral Mucosa Status in Patients with End-Stage Chronic Kidney Disease Undergoing Hemodialysis.

There are reports in the literature of interrelationships between chronic kidney disease and periodontitis pathophysiology; similar risk factors play a role in these conditions. Due to chronic kidney disease (CKD), patients on hemodialysis (HD) are more susceptible to developing pathological processes in the gingiva, periodontium, and oral mucosa. This study aimed to evaluate the condition of the oral cavity, with particular attention to lesions of the oral mucosa of patients with end-stage renal disease in Poland, West Pomeranian Voivodship. A case-control study assessed oral health in 200 Polish subjects, including 100 dialysis-station patients who constituted the study group (HD) and 100 healthy patients who formed the control group (K). The physical examination consisted of a general medical and dental history. Evaluation of the oral mucosa included detailed noting of the type of lesions, nature of complaints, and their location. The results showed a higher prevalence of oral lesions highlighting oral mucosal pathology in patients with HD than in group K. Most common symptoms reported by patients with CKD (HD) were xerostomia, taste disorders, and burning mouth. These findings highlight the need to implement comprehensive multispecialty care in patients with chronic systemic diseases.

Evaluation of Common Factors of Periodontitis and Cardiovascular Disease in Patients with the Acute Coronary Syndrome.

Periodontitis is a multifactorial disease causing inflammatory destruction of supporting structures of the dentition and eventually leading to its loss. This study was designed to evaluate common risk factors for periodontitis and acute coronary syndrome in the study population and demonstrate the systemic impact of periodontitis on the occurrence of acute coronary syndrome. A total of 160 patients (35 female and 125 male) were enrolled in the study. Considering the age range, the largest group of patients (118 patients) was between 55 and 65 years, which accounted for 73.8% of the total study population. There were 35 patients (21.9%) in the age group of 45 to 54 years, while the youngest age group of 35 to 44 years had as many as seven patients. Medical history and physical examination, including periodontal status, were performed. API, PD, CAL, and CPITN were evaluated. Common risk factors for periodontitis and acute coronary syndrome were assessed. The study assessed risk factors such as hypertension, diabetes, dyslipidemia, general health, smoking, height, weight, and hip circumference. In light of the above-described etiopathogenesis of atherosclerotic disease and its association with periodontal disease, it is important to emphasize preventing and treating periodontitis, especially in patients in the so-called high-risk group for cardiovascular disease. Dentists' introduction of an appropriate prophylactic and therapeutic plan may constitute both primary and secondary prevention of cardiovascular diseases.

Quality of Life in Patients with End-Stage Renal Disease Undergoing Hemodialysis.

End-stage renal disease and hemodialysis therapy cause a number of changes, not only somatic but also psychosocial, including the patient's perception and assessment of their quality of life. The literature describes predispositions to pathologies in the oral mucosa, craniofacial bones, teeth, and surrounding tissues in hemodialysis patients. This study aimed to determine the quality of life of hemodialysis patients in comparison with healthy subjects. The study group consisted of 200 subjects: the HD group (hemodialysis patients, n = 100) and the K group (control group, n = 100). General health and oral status were assessed using the following indices: plaque index, gingival index, probing depth, and clinical adhesion level. The WHOQOL-BREF survey was performed to determine both groups' overall quality of life. The results showed lower values of assessed quality-of-life parameters in hemodialysis patients compared to the control group, especially in the somatic sphere. General diseases such as oral mycosis, osteoporosis, rheumatoid arthritis, and coronary-artery disease negatively impact the perceived quality of life. There are numerous indications for comprehensive psychological care of hemodialysis patients due to their poor psychosocial status.

Comparison of the Treatment Efficacy of Endo-Perio Lesions Using a Standard Treatment Protocol and Extended by Using a Diode Laser (940 nm).

Marginal and periapical periodontal diseases cause massive destruction of tooth tissues and surrounding tissues, such as alveolar bone and maxillary sinus floor, visible on radiographs. Lesions involving the apical and marginal periodontium are endo-perio (EPL) lesions. This study aimed to compare the treatment efficacy of endo-perio lesions using a standard treatment protocol and a standard diode laser-assisted treatment protocol. The 12 patients were divided into the study (a) and control (b) group. Periodontal indices, tooth vitality and mobility, occlusal status, and radiographic diagnosis were evaluated. Standard EPL treatment was then performed-without (a) and with (b) the use of diode laser (940 nm). Again, after six months, the above-mentioned parameters were evaluated and compared. The treatment of endo-perio lesions is a significant challenge for modern dentistry. Diode lasers are increasingly used in addition to traditional treatment methods. The conventional use of a 940 nm diode laser with an average power of 0.8 W in pulsed mode allows for the depth of periodontal pockets to be reduced. In addition, the use of a diode laser has a significant effect on tooth mobility and reduces bone loss.

The Evaluation of the Periodontal Status of Hemodialysis Patients with End-Stage Renal Disease.

Chronic kidney disease (CKD) is an increasingly common condition observed in developing countries. Similarly, a high prevalence of gingivitis and periodontitis is observed. There are reports in the literature about the interrelationship between chronic kidney disease and periodontitis pathophysiology. This dissertation attempts to: assess the extent of gingivitis and periodontitis in a group of patients with the end-stage renal disease treated with hemodialysis compared to healthy subjects. The study included 200 subjects: 100 hemodialysis patients (HD) and 100 healthy control subjects (K). Periodontal status was assessed by measuring pocket depth (PD) clinical level of connective tissue attachment (CAL). Gingival inflammation indices Gingival Index (GI) and Bleeding on Probing (BOP) were also performed. PD with a depth of more than 6mm was found in 25% of the HD group and 5% of the K group. CAL ≥ 5 mm was found in 55% of HD and 24% of the K group. As defined by Page and Eke, severe periodontitis was found in 21% of HD, and 4% of K. Moderate gingivitis was noted in 55% of HD and 5% of the K group. The mean values of the BOP index in the HD group were 32.08% and in the K group 3.09%. The HD group had a higher incidence and severity of gingivitis and periodontitis than the control group.

Correlation of Panoramic Radiography, Cone-Beam Computed Tomography, and Three-Dimensional Printing in the Assessment of the Spatial Location of Impacted Mandibular Third Molars.

The development of radiology, rapid prototyping techniques, and the increasingly common use of 3D printing in dentistry inspires the use of these techniques to improve diagnostic and therapeutic processes. This study aimed to conduct a retrospective comparative analysis of dental panoramic radiographs, cone-beam computed tomography, and 3D printing in preoperative assessment of the procedure's difficulty. Thirty clinical cases with a high degree of difficulty were selected, and based on evaluation with CBCT, a virtual 3D model of the region of surgical procedure was created, which was then printed using a 3D printer. The comparative analysis included the linear measurements performed in dental panoramic radiographs, cone-beam computed tomography, and 3D models in a preoperative assessment of the degree of retention and difficulty of impacted mandibular third molars in the mandible. Linear measurements performed on dental panoramic radiographs were significantly lower than in cone-beam computed tomography and 3D models. No statistically significant differences were obtained in linear measurements between 3D models and cone-beam computed tomography images except for the measurement of the lingual lamina thickness; however, due to the insignificant differences in measurements, with a mean of only 80 µm, the elective procedure of removal of the impacted third molar in the mandible may be safe.

Association between Odontogenic and Maxillary Sinus Conditions: A Retrospective Cone-Beam Computed Tomographic Study.

Odontogenic infections can directly trigger maxillary sinusitis. CBCT is an excellent choice for precise examination of maxillary sinuses and hard tissues within the oral cavity. The objective of this retrospective and the cross-sectional study was to analyze the influence of odontogenic conditions on the presence and intensity of maxillary sinus mucous membrane thickening using CBCT imaging. Moreover, periodontal bone loss and anatomic relationship between adjacent teeth and maxillary sinuses were assessed to evaluate its possible impact on creating maxillary thickening. The study sample consisted of 200 maxillary sinuses of 100 patients visible on CBCT examination with a field of view of 13 × 15 cm. The presented study revealed a significant influence of periapical lesions, inappropriate endodontic treatment, severe caries, and extracted teeth on the presence of increased thickening of maxillary sinus mucous membrane. In addition, an increase in the distance between root apices and maxillary sinus floor triggered a significant reduction of maxillary sinus mucous membrane thickening. The presence of periodontal bone loss significantly increases maxillary sinus mucous membrane thickening.

Persisting bleeding from the duodenal ulcer in patients with occlusion of the celiac trunk: a case report.

INTRODUCTION: Endoscopic measures have continued to be the primary procedures in the management of ulcer bleeding. Nevertheless, in cases of failed endoscopic hemostasis and re-bleedings, endovascular techniques have gradually gained increased acceptance as an alternative to surgery, allowing to avoid surgical intervention in some cases. <br/> Case report: A case of a 42-year-old patient presenting to the authors' institution with massive bleeding from the duodenal ulcer, sprang from a pathologically enlarged gastroduodenal artery is reported. This vascular anomaly was a consequence of occlusion of the coeliac trunk (Dunbar syndrome), which was shown on an angio-CT scan. In spite of several endoscopic and endovascular measures, as well as three operations, the bleeding persistently recurred (a total of 6 episodes) and the patient eventually died. The article presents details of operative and endovascular treatments. Contemporary trends in management in cases of failed endoscopic interventions and re-bleedings form peptic ulcers are shown in the discussion.

Cerebral amyloid angiopathy-related inflammation (CAARI): case report.

Cerebral amyloid angiopathy-related inflammation is a new disease entity whose proper diagnosis may be difficult due to the fact that the early phase and radiological image resemble other conditions such as intracerebral haemorrhage or proliferative disorder. Also, the brain biopsy, which is an important part of the evaluation to confirm the diagnosis and rule out mimics, cannot be performed in each patient. In this paper we present the case of a 58yearold man who was correctly diagnosed with cerebral amyloid angiopathy-related inflammation (CAARI) based on the results of the histopathological examination of the brain tissue, which was possible mainly owing to the inclusion of the expansive process as the underlying cause in the initial differentiation. Further progression of the disease, despite applying treatment of increasing intensity in response to progressive deterioration of the patient's condition, revealed the multiplicity of clinical courses that a new and not easily pinpointed entity can take.

[64-slice computer tomography for diagnostics of the small bowel: computer tomography enteroclysis]. / Mozliwosci 64-warstwowej tomografii komputerowej w diagnostyce jelita cienkiego--enterokliza tomografii komputerowej.

INTRODUCTION: Radiologic imaging of the small bowel is the method of choice because other methods are of limited availability. Computer tomography (CT) enteroclysis is the leading modern method for diagnostic imaging of the small intestine. It combines the advantages of conventional small bowel infusion with those of abdominal CT and can serve to disclose a wide range of small bowel pathologies. MATERIAL AND METHODS: 101 patients underwent CT enteroclysis at the Department of Diagnostic Imaging and Interventional Radiology, Pomeranian Medical University in Szczecin. The procedure of CT enteroclysis is described starting from patient preparation and infusion technique to the scanning protocols. RESULTS: The results served to characterize the patients, establish indications and contraindications to CT enteroclysis, and reveal common errors of the method. CONCLUSIONS: Preliminary findings bring to light the considerable usefulness of CT enteroclysis. Other methods like ultrasound, MRI, conventional enteroclysis, or capsule endoscopy can be complementary in special cases.